Nitric oxide releasing derivatives of tolfenamic acid with anti-inflammatory activity and safe gastrointestinal profile

…, PT Eleftheriou, KC Tsiakitzis, PN Kourounakis

Index: Ziakas, George N.; Rekka, Eleni A.; Gavalas, Antonios M.; Eleftheriou, Phaedra T.; Tsiakitzis, Karyofillis C.; Kourounakis, Panos N. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 23 p. 6485 - 6492

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Citation Number: 15

Abstract

Tolfenamic acid esters with nitrooxyalcohols are synthesized. They are anti-inflammatory agents reducing carrageenan rat paw edema, with low gastrointestinal and general toxicity. In vitro, they are nitric oxide donors, inhibitors of lipoxygenase and cyclooxygenases. A two to three carbon chain between carboxylic and nitric ester groups seems optimal for activity.