Structure–activity relationships of pyrazole derivatives as potential therapeutics for immune thrombocytopenias

MK Purohit, SK Chakka, I Scovell, A Neschadim…

Index: Purohit, Meena K.; Chakka, Sai Kumar; Scovell, Iain; Neschadim, Anton; Bello, Angelica M.; Salum, Norue; Katsman, Yulia; Bareau, Madeleine C.; Branch, Donald R.; Kotra, Lakshmi P. Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 9 p. 2739 - 2752

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Citation Number: 9

Abstract

Abstract Idiopathic or immune thrombocytopenia (ITP) is a serious clinical disorder involving the destruction of platelets by macrophages. Small molecule therapeutics are highly sought after to ease the burden on current therapies derived from human sources. Earlier, we discovered that dimers of five-membered heterocycles exhibited potential to inhibit phagocytosis of human RBCs by macrophages. Here, we reveal a structure–activity ...