Experimentally induced phenylketonuria. I. Inhibitors of phenylalanine hydroxylase

…, WA Skinner, MC Theisen, C Mitoma

Index: DeGraw; Cory; Skinner; Theisen; Mitoma Journal of medicinal chemistry, 1967 , vol. 10, # 1 p. 64 - 66

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Citation Number: 18

Abstract

Among the non-o-dihydroxy conipounds tested, 4- fluorophenylalanine was the most potent inhibitor. 4- Fluorophenylalanine was reported to act as a substrate for PA hydroxylase'O and to inhibit the hydroxylation of phenylalanine competitively. Our studies showed that a-methyl derivatives of DOP-4 and 4-fluorophenyl- alanine were considerably less active as inhibitors than their respective parent compounds. Furthermore, 4- fluorocinnamic, -phenylarctic, ...