Hypotensive Agents. Pyridinecarboxamides and Piperidinecarboxamides1

J Sam, WF Minor, YG Perron

Index: Sam et al. Journal of the American Chemical Society, 1959 , vol. 81, p. 710,711

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Citation Number: 14

Abstract

The high physiological activity of many substituted piperidines, combined with the availability of a convenient and facile method of preparation of pyridinecarboxamides, prompted the preparation for pharmacologic evaluation of a number of piperidinecarboxylic acid derivatives. The use of alkyl carbonic-carboxylic acid mixed anhydrides for the preparation of amides4 has become of increasing importance, especially in the synthesis ...