Nucleic acid derived allenols. Unusual analogs of nucleosides with antiretroviral activity

S Phadtare, J Zemlicka

Index: Phadtare, Shashikant; Zemlicka, Jiri Journal of the American Chemical Society, 1989 , vol. 111, # 15 p. 5925 - 5931

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Citation Number: 72

Abstract

Conclusions The well-known rapid hydrolysis of amic acids in acidic solution involves a transacylation reaction, which potentially competes initially with a dehydration reaction leading to formation of an imide. The pseudoequilibrium between amic acid and imide is drained by the conversion of the amic acid to the amine and dicarboxylic acid via the anhydride. This complication in the behavior of amic acids indicates that changes in the ...