Synthesis of (R)-serine-2-d and its conversion to the broad-spectrum antibiotic fludalanine
PJ Reider, RSE Conn, P Davis, VJ Grenda…
Index: Journal of Organic Chemistry, , vol. 52, # 15 p. 3326 - 3334
Full Text: HTML
Citation Number: 36
Abstract
... With the advent of the requirement for large quantities of Fludalanine (1, MK-641) we had to address the practical and economical introduction of deuterium into an organic molecule. ... Scheme IV 0-i-Pr I , IV Y r 8 =(,RAr - 0 J. Org. Chem., Vol. 52, No. 15, 1987 3329 ...
Related Articles:
(S)-Serine derived N–O and N–P oxazoline ligands for asymmetric catalysis
[Jones, Geraint; Richards, Christopher J. Tetrahedron Asymmetry, 2004 , vol. 15, # 4 p. 653 - 664]
[Tetrahedron Letters, , vol. 53, # 32 p. 4121 - 4123]
A Facile Synthesis of Oxazolines, Thiazolines, and Imidazolines Using α, α-Difluoroalkylamines
[Fukuhara, Tsuyoshi; Hasegawa, Chihiro; Hara, Shoji Synthesis, 2007 , # 10 p. 1528 - 1534]
Synthesis of (R)-serine-2-d and its conversion to the broad-spectrum antibiotic fludalanine
[Reider; Eichen Conn; Davis; et al. Journal of Organic Chemistry, 1987 , vol. 52, # 15 p. 3326 - 3334]
Catalytic asymmetric hydrogenation of N-Boc-imidazoles and oxazoles
[Journal of the American Chemical Society, , vol. 133, # 19 p. 7312 - 7315]