Tetrahedron Letters

Application of directed metallation in synthesis: total synthesis of model compounds related to semivioxanthin

S Kamila, C Mukherjee, A De

Index: Kamila, Sukanta; Mukherjee, Chandrani; De, Asish Tetrahedron Letters, 2001 , vol. 42, # 34 p. 5955 - 5957

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Citation Number: 12

Abstract

The undiminished importance of heteroatom directed ortho metallation 1 as an effective tool in synthetic aromatic chemistry is corroborated by its continuing use in regioselective functionalisation of aromatic or heteroaromatic nuclei and the subsequent utilization of the introduced functionalities for annelation purposes. We report here the application of this methodology for the synthesis of two model compounds 1 and 2 related to the naturally occurring antifungal compound ...

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