Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins
Y Tanaka, K Aikawa, G Nishida, M Homma…
Index: Hickey, Deirdre M. B.; Moody, Christopher J.; Rees, Charles W. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1119 - 1122
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Citation Number: 42
Abstract
... Journal of Medicinal ... J. Med. ... The discovery of compound 1 (ABT-737, Figure 1)(12-16) and the closely related compound 2 (ABT-263, Figure 1) was a notable success reported by Abbott Laboratories.(17-22) These compounds inhibit Bcl-xL, Bcl-2, and Bcl-w with high affinities ...
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