Tetrahedron

A convenient synthesis of thiazolopyrimidines, thiazolodipyrimidines and heterocyclothiazolopyrimidines

…, MM Youssef, KM Mobarak, ASM Abdel-Fattah

Index: Sherif; Youssef; Mobarak; Abdel-Fattah Tetrahedron, 1993 , vol. 49, # 42 p. 9561 - 9572

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Citation Number: 48

Abstract

Ethyl 4-aryl-6-substituted-2-thioxo-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates 1 reacted with bromomalononitrile (2) to give ethyl 3-amino-5-aryl-2-cyano-7-substituted-5H-thiazolo [3, 2-a] pyrimidine-6-carboxylates 3. The latter compounds reacted with formic acid, hydroxylamine hydrochloride and with formamide to give 9H-3, 4-dihydrothiazolo [3, 2-a: 4, 5-b] dipyrimidine-8-carboxylates 5, 1H, 8H-pyrazolo [3, 4-d] thiazolo [3, 2-a] pyrimidine-7- ...