Discovery of 3H??Imidazo [4, 5??b] pyridines as Potent c??Met Kinase Inhibitors: Design, Synthesis, and Biological Evaluation

D Chen, Y Wang, Y Ma, B Xiong, J Ai, Y Chen…

Index: ChemMedChem, , vol. 7, # 6 p. 1057 - 1070

Full Text: HTML

Citation Number: 7

Abstract

... ChemMedChem, 7: 1057–1070. ... 4-fluorobenzoic acid, and polyphosphoric acid were heated at 250 °C for 4 h to provide oxazolopyridine 7, which was ... Tumor-bearing nude mice were randomly divided into groups after tumor volume (V tum ) reached 100–200 mm 3 and were ...