New 2-thiopyridines as potential candidates for killing both actively growing and dormant Mycobacterium tuberculosis cells

…, O Ryabova, A Kaprelyants, V Makarov

Index: Salina, Elena; Ryabova, Olga; Kaprelyants, Arseny; Makarov, Vadim Antimicrobial Agents and Chemotherapy, 2014 , vol. 58, # 1 p. 55 - 60

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Citation Number: 12

Abstract

ABSTRACT From in vivo observations, a majority of M. tuberculosis cells in latently infected individuals are in a dormant and probably nonculturable state, display little metabolic activity, and are phenotypically resistant to antibiotics. Despite many attempts, no specific antimicrobials effective against latent tuberculosis have yet been found, partly because of a lack of reliable and adequate in vitro models for screening of drug candidates. We ...