One-pot synthesis of 2-trifluoromethylchromones

…, SE Ulic, CO Della Védova, N Metzler-Nolte, JL Jios

Index: Castaneda, Isabel C. Henao; Ulic, Sonia E.; Vedova, Carlos O. Della; Metzler-Nolte, Nils; Jios, Jorge L. Tetrahedron Letters, 2011 , vol. 52, # 13 p. 1436 - 1440

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Citation Number: 11

Abstract

We report a simple and suitable method for the preparation of useful 2- trifluoromethylchromones in one step, in high yields and avoiding the use of solvents. We were able to detect the intermediate of this reaction. Furthermore a mechanism for the formation of the 7-methoxy-3-trifluoroacetyl-2-trifluoromethylchromone through the unexpected double trifluoroacetylation of 4-methoxy-2-hydroxyacetophenone followed by ...