Highly enantioselective desymmetrizations of meso-anhydrides
E Schmitt, I Schiffers, C Bolm
Index: Schmitt, Ellen; Schiffers, Ingo; Bolm, Carsten Tetrahedron, 2010 , vol. 66, # 33 p. 6349 - 6357
Full Text: HTML
Citation Number: 21
Abstract
Readily available, low molecular cyclohexane-based organocatalysts promote highly enantioselective desymmetrizations of cyclic meso-anhydrides applying alcohols and benzyl mercaptan as nucleophiles. Both succinic and glutaric anhydrides furnished the corresponding products with up to 96% ee in mostly quantitative yields.
Related Articles:
Cross-linked crystals of subtilisin: versatile catalyst for organic synthesis
[Wang, Yi-Fong; Yakovlevsky, Kirill; Zhang, Bailing; Margolin, Alexey L. Journal of Organic Chemistry, 1997 , vol. 62, # 11 p. 3488 - 3495]