Quaternary aminooxy congeners of acetyl. gamma.-homocholine

JG Cannon, PJ Mulligan, JE Garst…

Index: Cannon,J.G. et al. Journal of Medicinal Chemistry, 1973 , vol. 16, p. 287 - 289

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Abstract

A prior communication'described preparation and biological effects of a series of N- methoxylated analogs 1-4 of certain cholinergic agents related to acetylcholine. These methoxyammonium compounds, with one exception, exhibited a low order of cholinergic activity. The unexpected and unexplained dramatically high muscarinic activity of 4, the N- methoxy congener of Bethanechol, suggested further investigation of simple cholinergic ...