Tetrahedron

One-pot synthesis of meridianins and meridianin analogues via indolization of nitrosoarenes

…, M Simonetti, KM Nicholas, G Palmisano, M Parravicini…

Index: Tibiletti, Francesco; Simonetti, Marco; Nicholas, Kenneth M.; Palmisano, Giovanni; Parravicini, Matteo; Imbesi, Federico; Tollari, Stefano; Penoni, Andrea Tetrahedron, 2010 , vol. 66, # 6 p. 1280 - 1288

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Citation Number: 36

Abstract

Meridianins, marine alkaloids known as kinase inhibitors with an indole skeleton, and meridianin analogues were produced regioselectively and in moderate to good yields by thermal annulation of nitrosoarenes with 2-amino-4-ethynylpyrimidine and 2-chloro-4- ethynylpyrimidine, respectively, through a novel and atom-economical indolization process.