Expanding the palette of phenanthridinium cations

AG Cairns, HM Senn, MP Murphy…

Index: Cairns, Andrew G.; Senn, Hans Martin; Murphy, Michael P.; Hartley, Richard C. Chemistry - A European Journal, 2014 , vol. 20, # 13 p. 3742 - 3751

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Citation Number: 4

Abstract

Abstract 5, 6-Disubstituted phenanthridinium cations have a range of redox, fluorescence and biological properties. Some properties rely on phenanthridiniums intercalating into DNA, but the use of these cations as exomarkers for the reactive oxygen species (ROS), superoxide, and as inhibitors of acetylcholine esterase (AChE) do not require intercalation. A versatile modular synthesis of 5, 6-disubstituted phenanthridiniums that introduces ...