Synthesis and structure of molecular tweezers containing active site functionality

SC Zimmerman, Z Zeng, W Wu…

Index: Zimmerman, Steven C.; Zeng, Zijian; Wu, Weiming; Reichert, David E. Journal of the American Chemical Society, 1991 , vol. 113, # 1 p. 183 - 196

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Citation Number: 66

Abstract

Abstract: A series of molecules has been synthesized in which a functional group is buried inside an aromatic binding cleft. These novel compounds, called “molecular tweezers”, have a methyl ester (6a, 7-9a, loa), a carboxylic acid (6b, 9b, lob, 45), or a nitrile (50) in their clefts. Molecular tweezer 21 has a metal ligand, an annelated terpyridine, oriented toward the binding cleft. The structures of 7-10 have been determined either by X-ray analysis or by ...