Tetrahedron letters

An improved synthesis of a fluorescent gabapentin–choline conjugate for single molecule detection

H Wu, G Kaur, GL Griffiths

Index: Wu, Haitao; Kaur, Gurpreet; Griffiths, Gary L. Tetrahedron Letters, 2009 , vol. 50, # 18 p. 2100 - 2102

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Citation Number: 8

Abstract

Voltage-gated calcium ion channels comprise pore-forming α1 and auxiliary α2δ, β, and γ subunits. They are important molecular devices involved in a variety of cell functions. Fluorescently labeled acylcholine analogues are important in studies such as ion channel regulation. Cy3-3-acetylcholine has recently been synthesized for single molecule detection studies; albeit in an extremely low overall yield (0.06%). In this work, an alternative route ...