The pH of HNO donation is modulated by ring substituents in Piloty's acid derivatives: azanone donors at biological pH

…, SA Suárez, DE Bikiel, F Doctorovich

Index: Sirsalmath, Kiran; Suarez, Sebastian A.; Bikiel, Damian E.; Doctorovich, Fabio Journal of Inorganic Biochemistry, 2013 , vol. 118, p. 134 - 139

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Citation Number: 15

Abstract

A group of Piloty's acid (N-hydroxybenzenesulfonamide) derivatives were synthesized and fully characterized in order to assess the rates and pH of HNO (azanone, nitroxyl) donation in aqueous media. The derivatives, with electron-withdrawing and-donating substituents include methyl, nitro, fluoro, tri-isopropyl, trifluoromethyl and methoxy groups. The most interesting modulation observed is the change in pH range in which the compounds are ...