Investigation on the chemoenzymatic synthesis of threo-and erythro-β-hydroxy-L-glutamic acid derivatives

…, C De Micheli, G Roda, P Magrone, R Pizzoli…

Index: Sagui, Francesca; De Micheli, Carlo; Roda, Gabriella; Magrone, Pietro; Pizzoli, Rachele; Riva, Sergio Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 75, p. 27 - 34

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Citation Number: 2

Abstract

A derivative of the malonic semialdehyde was transformed by means of a bioconversion catalyzed by the enzyme l-threonine aldolase from E. coli into a 6: 4 epimeric mixture of two precursors of β-hydroxy glutamic acid. The enzyme was selective for the formation of the (S)- configuration at C-2, whereas the configuration at C-3 was not controlled. The two epimers were separated exploiting a diastereoselective acylation in organic solvent catalyzed by ...