Chemoenzymatic synthesis of the potential antihypertensive agent (2R, 2′ S)-β-hydroxyhomometoprolol

…, A Torres-Gavilán, A López-Munguía, E Castillo

Index: Regla, Ignacio; Luviano-Jardon, Axel; Demare, Patricia; Hong, Enrique; Torres-Gavilan, Alejandro; Lopez-Munguia, Agustin; Castillo, Edmundo Tetrahedron Asymmetry, 2008 , vol. 19, # 21 p. 2439 - 2442

Full Text: HTML

Citation Number: 7

Abstract

The kinetic resolution of 1-chloro-3-[4-(2-methoxyethyl) phenoxy]-2-propanol rac-4 with Novozym 435 and vinyl stearate, a key step in the gram-scale synthesis of (2S)-2-[[(2R)-2- hydroxy-3-[4-(2-methoxyethyl) phenoxy] propyl] amino]-1-butanol (R, S)-1 a potent antihypertensive agent currently under investigation, is reported here. Our approach differs from the previously reported synthesis, which involves a tedious and poorly effective ...

Synthesis of β??Chlorohydrins in Water

[Das, Biswanath; Venkateswarlu, Katta; Krishnaiah, Maddeboina Helvetica Chimica Acta, 2007 , vol. 90, # 1 p. 149 - 152]

Synthesis and cardiovascular activity of metoprolol analogues

[Melgar-Fernandez, Roberto; Demare, Patricia; Hong, Enrique; Rosas, Miguel Angel; Escalante, Jaime; Munoz-Muniz, Omar; Juaristi, Eusebio; Regla, Ignacio Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 191 - 194]

Synthesis and cardiovascular activity of metoprolol analogues

Chemoenzymatic synthesis of the potential antihypertensive agent (2R, 2′ S)-β-hydroxyhomometoprolol

Abstract

Related Articles:

More Articles...