A new and practical procedure for the bruylants reaction. Zinc-mediated synthesis of tertiary homoallylamines and β-aminoesters
…, E Capito, G Dessole, M Fochi, M Comes-Franchini…
Index: Bernardi, Luca; Bonini, Bianca F.; Capito, Elena; Dessole, Gabriella; Fochi, Mariafrancesca; Comes-Franchini, Mauro; Ricci, Alfredo Synlett, 2003 , # 12 p. 1778 - 1782
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Citation Number: 3
Abstract
Abstract N, N-Disubstituted α-aminonitriles undergo Bruylants reaction under Barbier and Reformatsky conditions with activated halides, in the presence of zinc and 10 mol% HOAc. The high yields and the simple operational conditions make this reaction an appealing approach to N, N-disubstituted homoallylamines and β-aminoesters.
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