Using mixed self-assembled monolayers presenting RGD and (EG) 3OH groups to characterize long-term attachment of bovine capillary endothelial cells to surfaces

…, M Mrksich, V Martichonok, DE Ingber…

Index: Roberts, Carmichael; Chen, Christopher S.; Mrksich, Milan; Martichonok, Valerie; Ingber, Donald E.; Whitesides, George M. Journal of the American Chemical Society, 1998 , vol. 120, # 26 p. 6548 - 6555

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Citation Number: 367

Abstract

This paper describes surfaces that promote the ligand-directed binding of cells and resist the cellular deposition of adhesive proteins. These surfaces are based on self-assembled monolayers (SAMs) of alkanethiolates on gold that present mixtures of arginine-glycine- aspartate (RGD), a tripeptide that promotes cell adhesion by binding to cell surface integrin receptors, and oligo (ethyleneglycol) moieties, groups that resist nonbiospecific ...