New pyrrolidin-, piperidin-and azepin-2-oxocarboxylic acid esters are preferential M1, M3 muscarinic antagonists. Synthesis and bronchospasmolytic activity

…, A Ezhaya, E Bellora, GB Schiavi, A Sagrada…

Index: Cereda; Ezhaya; Bellora; Schiavi; Sagrada; Doods; Donetti European Journal of Medicinal Chemistry, 1994 , vol. 29, # 6 p. 411 - 421

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Citation Number: 2

Abstract

Abstract A series of new 3-tropanol and 3-quinuclidinol esters of phenyl-substituted pyrrolidin-, piperidin-and azepin-2-oxocarboxylic acid were synthesized and tested for antimuscarinic activity. The compounds showed a preferential in vitro activity at M 1 and M 3 receptor subtypes and an interesting activity profile in vivo. A potential use as selective bronchospasmolytic agents has been suggested for selected compounds.