Enantioselective synthesis of (R)-bufuralol via dynamic kinetic resolution in the key step

EV Johnston, K Bogár, JE Bäckvall

Index: Johnston, Eric V.; Bogar, Krisztian; Baeckvall, Jan-E. Journal of Organic Chemistry, 2010 , vol. 75, # 13 p. 4596 - 4599

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Citation Number: 24

Abstract

An enantioselective synthesis of (R)-bufuralol via a ruthenium-and enzyme-catalyzed dynamic kinetic resolution (DKR) has been achieved. The synthesis starts from readily available 2-ethylphenol and provides (R)-bufuralol in high ee and a good overall yield of 31%.