Chemical Communications

Asymmetric Friedel–Crafts reaction of N-heterocycles and nitroalkenes catalyzed by imidazoline–aminophenol–Cu complex

N Yokoyama, T Arai

Index: Yokoyama, Naota; Arai, Takayoshi Chemical Communications, 2009 , # 22 p. 3285 - 3287

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Citation Number: 46

Abstract

As symbolized by the potent alkaloid strychnine, various highly functionalized N-heterocycles (eg, indoles and/or pyrroles) have been isolated from natural sources. 1 Because the structural complexity of these molecules is obviously linked to their significant biological activity, the development of an efficient method for the synthesis of N-heterocyclic derivatives in an optically active form is currently in high demand in organic chemistry. Moreover, a new class of artificial N- ...