Tetrahedron Letters

An enantioselective synthesis of the C 2–C 16 segment of antitumor macrolide laulimalide

AK Ghosh, Y Wang

Index: Ghosh, Arun K.; Wang, Yong Tetrahedron Letters, 2000 , vol. 41, # 14 p. 2319 - 2322

Full Text: HTML

Citation Number: 41

Abstract

An enantioselective synthesis of the C2–C16 segment of the novel antitumor agent laulimalide is described. The key steps involve a highly diastereoselective allylation, ring- closing olefin metathesis of a homoallylic alcohol derived acrylate ester, a stereoselective anomeric alkylation and an elaboration of an exo-methylene unit by a Julia olefination reaction.