Spirocyclic NK 1 antagonists II:[4.5]-spiroethers

…, T Harrison, AP Owens, SN Owen, NMJ Rupniak…

Index: Williams, Brian J.; Cascieri, Margaret A.; Chicchi, Gary G.; Harrison, Timothy; Owens, Andrew P.; Owen, Simon N.; Rupniak, Nadia M.J.; Tattersall, David F.; Williams, Angela; Swain, Christopher J. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 19 p. 2719 - 2722

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Citation Number: 13

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of novel spiroether-based neurokinin-1 (NK 1 ) antagonists is described. The effect of modifications to the spiroether ring and aromatic substituents are discussed, leading to the identification of compounds with high affinity and excellent CNS penetration.