Organic letters

Suzuki coupling of oxazoles

E Ferrer Flegeau, ME Popkin, MF Greaney

Index: Flegeau, Emmanuel Ferrer; Popkin, Matthew E.; Greaney, Michael F. Organic Letters, 2006 , vol. 8, # 12 p. 2495 - 2498

Full Text: HTML

Citation Number: 69

Abstract

A protocol for the functionalization of the oxazole 2-and 4-positions using the Suzuki coupling reaction is described. 2-Aryl-4-trifloyloxazoles undergo rapid, microwave-assisted coupling with a range of aryl and heteroaryl boronic acids in good to excellent yields. The methodology is similarly effective using 4-aryl-2-chlorooxazoles as the coupling partner and has been extended to the synthesis of a novel class of homo-and heterodimeric 4, 4- ...