Total synthesis of dictyodendrins A–E

H Tokuyama, K Okano, H Fujiwara…

Index: Tokuyama, Hidetoshi; Okano, Kentaro; Fujiwara, Hideto; Noji, Toshiharu; Fukuyama, Tohru Chemistry - An Asian Journal, 2011 , vol. 6, # 2 p. 560 - 572

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Citation Number: 25

Abstract

Abstract A highly efficient total synthesis of dictyodendrins A–E was accomplished. The synthesis features a novel benzyne-mediated one-pot indoline formation/cross-coupling sequence for the construction of a highly substituted key indoline intermediate. Peripheral substituents were introduced onto this intermediate in a modular fashion to complete the total synthesis of dictyodendrins A–E. Abstract