Discovery of new chemical leads for prostaglandin D 2 receptor antagonists

K Torisu, K Kobayashi, M Iwahashi, H Egashira…

Index: Torisu, Kazuhiko; Kobayashi, Kaoru; Iwahashi, Maki; Egashira, Hiromu; Nakai, Yoshihiko; Okada, Yutaka; Nanbu, Fumio; Ohuchida, Shuichi; Nakai, Hisao; Toda, Masaaki Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4557 - 4562

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Citation Number: 19

Abstract

A series of Indomethacin analogs were synthesized and biologically evaluated. Among the compounds tested, N-(p-butoxy) benzoyl-2-methylindole-4-acetic acid 2 was discovered as a new chemical lead for a prostaglandin D2 (PGD2) receptor antagonist. Structure–activity relationship data are also presented.