Synthesis of 2-(Pyridin-3-yl)-1-azabicyclo [3.2. 2] nonane, 2-(Pyridin-3-yl)-1-azabicyclo [2.2. 2] octane, and 2-(Pyridin-3-yl)-1-azabicyclo [3.2. 1] octane, a Class of …

BS Bhatti, JP Strachan, SR Breining…

Index: Strachan, Jon-Paul; Whitaker, Regina C.; Miller, Craig H.; Bhatti, Balwinder S. Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9909 - 9911

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Citation Number: 11

Abstract

In an attempt to generate nicotinic acetylcholine receptor (nAChR) ligands selective for the α4β2 and α7 subtype receptors we designed and synthesized constrained versions of anabasine, a naturally occurring nAChR ligand. 2-(Pyridin-3-yl)-1-azabicyclo [2.2. 2] octane, 2-(pyridin-3-yl)-1-azabicyclo [3.2. 2] nonane, and several of their derivatives have been synthesized in both an enantioselective and a racemic manner utilizing the same basic ...