Renin inhibitory peptides. Incorporation of polar, hydrophilic end groups into an active renin inhibitory peptide template and their evaluation in a human renin-infused …

S Thaisrivongs, DT Pals, DW DuCharme…

Index: Thaisrivongs; Pals; DuCharme; Turner; DeGraaf; Lawson; Couch; Williams Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 633 - 642

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Citation Number: 20

Abstract

We previously reported that Boc-Pro-Phe-N-MeHis-Leu~[CHOHCH2]-Ile-Amp (1) is a potent and specific inhibitor of human renin in vitro. It was shown to resist degradation by selected proteases and a rat liver homogenate. It was shown to inhibit plasma renin activity and to reduce blood pressure in renin-dependent-animal models both by the intravenous and by the oral routes using dilute citric acid as vehicle. In an effort to discover compounds with ...