European journal of medicinal chemistry

Variations of acidic functions at position 2 and substituents at positions 4, 5 and 6 of the indole moiety and their effect on NMDA-glycine site affinity

M Jansen, G Dannhardt

Index: Jansen, Michaela; Dannhardt, Gerd European Journal of Medicinal Chemistry, 2003 , vol. 38, # 10 p. 855 - 865

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Citation Number: 10

Abstract

The synthetic procedures to obtain indole derivatives with different acidic functions at position 2 of the indole are reported. The synthesised and tested derivatives comprise 5- tetrazolyl, 1, 3, 4-oxadiazol-5-yl-2-one, and indole-2-carboxylic acid amides with 5- aminotetrazole, methanesulphonamide and trifluoromethanesulphonamide moieties. The binding affinity was evaluated using [3H] MDL 105,519 and pig cortical brain membranes. ...