Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry
…, P Acharya, R Wyatt, PD Kwong, CA Bewley
Index: Lam, Son N.; Acharya, Priyamvada; Wyatt, Richard; Kwong, Peter D.; Bewley, Carole A. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 23 p. 10113 - 10120
Full Text: HTML
Citation Number: 33
Abstract
The HIV-1 co-receptor CCR5 possesses sulfo-tyrosine (TYS) residues at its N-terminus (Nt) that are required for binding HIV-1 gp120 and mediating viral entry. By using a 14-residue fragment of CCR5 Nt containing two TYS residues, we recently showed that CCR5 Nt binds gp120 through a conserved region specific for TYS moieties and suggested that this site may represent a target for inhibitors and probes of HIV-1 entry. As peptides containing ...
Related Articles:
Synthesis and cellular properties of Near-IR BODIPY–PEG and carbohydrate conjugates
[Uppal, Timsy; Bhupathiraju, N.V.S. Dinesh K.; Vicente, M. Graca H. Tetrahedron, 2013 , vol. 69, # 23 p. 4687 - 4693]
Zinc (II) cyclen–peptide conjugates interacting with the weak effector binding state of Ras
[Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48]
[Canaria, Christie A.; Smith, Jeffrey O.; Yu; Fraser, Scott E.; Lansford, Rusty Tetrahedron Letters, 2005 , vol. 46, # 28 p. 4813 - 4816]
Preparation and biological properties of biotinylated PhTX derivatives
[Hashimoto, Masaru; Liu, Ying; Fang, Kan; Li, Hong-Yu; Campiani, Giuseppe; Nakanishi, Koji Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 6 p. 1181 - 1194]
Preparation and biological properties of biotinylated PhTX derivatives
[Hashimoto, Masaru; Liu, Ying; Fang, Kan; Li, Hong-Yu; Campiani, Giuseppe; Nakanishi, Koji Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 6 p. 1181 - 1194]