Targeted and armed oncolytic adenovirus via chemoselective modification

PS Banerjee, ES Zuniga, I Ojima, IS Carrico

Index: Banerjee, Partha S.; Zuniga, Edison S.; Ojima, Iwao; Carrico, Isaac S. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 17 p. 4985 - 4988

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Citation Number: 9

Abstract

Oncolytic adenoviruses (Ads) are an emerging alternative therapy for cancer; however, clinical trial have not yet demonstrated sufficient efficacy. When oncolytic Ads are used in combination with taxoids a synergistic increase in both cytotoxicity and viral replication is observed. In order to generate a next generation oncolytic adenovirus, virion were physically conjugated to a highly potent taxoid, SB-T-1214, and a folate targeting motif. Conjugation ...