Development of a Fit-for-Purpose Large-Scale Synthesis of an Oral PARP Inhibitor
DJ Wallace, CA Baxter, KJM Brands…
Index: Organic Process Research and Development, , vol. 15, # 4 p. 831 - 840
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Abstract
... Organic Process Research & Development. ... Process Res. ... step, however careful control of reagent charge was required as this protocol also led to some further debromination to starting material 9. On the basis of these issues it appeared the bromination procedure would likely ...
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Development of a Fit-for-Purpose Large-Scale Synthesis of an Oral PARP Inhibitor
[Wallace, Debra J.; Baxter, Carl A.; Brands, Karel J. M.; Bremeyer, Nadine; Brewer, Sarah E.; Desmond, Richard; Emerson, Khateeta M.; Foley, Jennifer; Fernandez, Paul; Hu, Weifeng; Keen, Stephen P.; Mullens, Peter; Muzzio, Daniel; Sajonz, Peter; Tan, Lushi; Wilson, Robert D.; Zhou, George; Zhou, Guoyue Organic Process Research and Development, 2011 , vol. 15, # 4 p. 831 - 840]