Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl] butyl]-3-(3-pyridyl) acrylamides

…, T Shindo, K Ishii, H Nakamura, T Kon…

Index: Nishikawa; Shindo; Ishii; Nakamura; Kon; Uno Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 583 - 593

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Citation Number: 35

Abstract

PO in the rat PCA test, which was one-fifth of ketotifen and oxatomide. As compared with ketotifen and oxatomide, compound 17p (AL-3264) possessed a better balance of antiallergic properties due to inhibition of chemical mediator release, inhibition of 5- lipoxygenase, and antagonism of histamine.

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