Structure and activity relationships of novel uracil derivatives as topical anti-inflammatory agents

Y Isobe, M Tobe, Y Inoue, M Isobe, M Tsuchiya…

Index: Isobe, Yoshiaki; Tobe, Masanori; Inoue, Yoshifumi; Isobe, Masakazu; Tsuchiya, Masami; Hayashi, Hideya Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 4933 - 4940

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Citation Number: 31

Abstract

In order to create novel, topical anti-inflammatory compounds exhibiting more potent activities than lead compound CX-659S (1), we designed and synthesized various derivatives of 1 focusing on the uracil N (1)-and N (3)-substituents, and evaluated their anti- inflammatory activities via inhibition of the picryl chloride-induced contact hypersensitivity reaction (CHR) in mice. In the course of our structure and activity relationship study, we ...