Bioorganic & medicinal chemistry

Solid-phase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide incorporating 7-deazaguanine bases

ML Jain, TC Bruice

Index: Jain, Moti L.; Bruice, Thomas C. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 21 p. 7333 - 7346

Full Text: HTML

Citation Number: 14

Abstract

DNG nucleotides represent a positively charged DNA analog in which the negatively charged phosphodiester linkages of DNA are replaced by positively charged guanidinium linkages. We report herein the synthesis of 3′-end, middle, and 5′-end monomers required for the synthesis of a DNG sequence in which the natural guanine base is replaced by 7-deazaguanine (c7G). 7-Deazaguanine nucleobase was chosen because of their ...

Related Articles:

A facile synthesis of tubercidin and related 7-deazapurine nucleosides via the stereospecific sodium salt glycosylation procedure

[Ramasamy; Imamura; Robins; Revankar Tetrahedron Letters, 1987 , vol. 28, # 43 p. 5107 - 5110]

A facile and improved synthesis of tubercidin and certain related pyrrolo [2, 3??d] pyrimidine nucleosides by the stereospecific sodium salt glycosylation procedure

[Ramasamy; Imamura; Robins; Revankar Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 6 p. 1893 - 1898]

Synthesis of 2-amino-7-(2'-deoxy-. beta.-D-erythro-pentofuranosyl)-3, 7-dihydro-4H-pyrrolo [2, 3-d] pyrimidin-4-one, a new isostere of 2'-deoxyguanosine

[Winkeler, Heinz-Dieter; Seela, Frank Journal of Organic Chemistry, 1983 , vol. 48, # 18 p. 3119 - 3122]

More Articles...