Chemical research in toxicology

Metabolism of N'-nitrosonornicotine enantiomers by cultured rat esophagus and in vivo in rats

EJ McIntee, SS Hecht

Index: McIntee, Edward J.; Hecht, Stephen S. Chemical Research in Toxicology, 2000 , vol. 13, # 3 p. 192 - 199

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Citation Number: 31

Abstract

People who use tobacco products are exposed to considerable amounts of N'- nitrosonornicotine (NNN), a well-established esophageal carcinogen in rats. NNN is believed to play a significant role as a cause of esophageal and oral cavity cancer in smokers and snuff dippers. The carcinogenicity of NNN is dependent on its metabolic activation. However, virtually all studies carried out to date on NNN metabolism have used ...