Anti-mycobacterial 7-hydroxy-2, 3-dihydro-1H-indolizin-5-ones

G Dannhardt, W Meindl, S Gussmann, S Ajili…

Index: Dannhardt; Meindl; Gussmann; Ajili; Kappe European Journal of Medicinal Chemistry, 1987 , vol. 22, # 6 p. 505 - 510

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Citation Number: 16

Abstract

Abstract 7-Hydroxy-2, 3-dihydro-1H-indolizin-5-ones with various substituents as well as their pyranno annelated derivatives were synthesized by reaction of Δ 1-pyrrolines with 'magic malonates'(activated malonates). The evaluation of these compounds on Mycobacterium tuberculosis H37Ra, Escherichia coli B and Staphylococcus aureus ATCC 25923, shows significant inhibitory effects on M. tuberculosis (3b and 3f, MIC= 16 μg/ml). A ...