Expeditious synthesis of nicotianamine and 2′-deoxymugineic acid
K Miyakoshi, J Oshita, T Kitahara
Index: Miyakoshi, Katsuhiro; Oshita, Jun; Kitahara, Takeshi Tetrahedron, 2001 , vol. 57, # 16 p. 3355 - 3360
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Citation Number: 32
Abstract
A simple and efficient method of synthesizing nicotianamine 4 and 2′-deoxymugineic acid 3 was devised. We employed thioamide as an intermediate and the title compounds (4 and 3) were afforded via chemoselective reduction of the thioamides in 33% overall yield through 7 steps and 30% overall yield through 8 steps, respectively.
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