Esters of nipecotic and isonipecotic acids as potential anticonvulsants

AM Crider, TT Tita, JD Wood…

Index: Crider; Tita; Wood; Hinko Journal of Pharmaceutical Sciences, 1982 , vol. 71, # 11 p. 1214 - 1219

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Citation Number: 21

Abstract

Abstract A variety of esters of nipecotic and isonipecotic acids were synthesized and evaluated for anticonvulsant activity. The ester group was varied in terms of lipophilicity and reactivity toward hydrolysis. The esters were screened against seizures induced by electroshock, pentylenetetrazol, and the putative γ-aminobutyric acid antagonist, bicuculline. The most significant activity was demonstrated by the p-nitrophenyl esters of nipecotic and ...

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