Betuligenol derivative with growth inhibition and antifeedant activity

SK Chattopadhyay, S Srivastava, KV Sashidhara…

Index: Chattopadhyay, Sunil K.; Srivastava, Sachin; Sashidhara, Koneni V.; Tripathi, Arun K.; Bhattacharya, Asish K.; Negi, Arvind S. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 7 p. 1729 - 1731

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Citation Number: 8

Abstract

The title chiral amine, 3-(4-methoxyphenyl)-1-methylpropylamine 5 has been synthesized from naturally abundant betuligenol 1 in three steps and also in good yield. Furthermore, the versatile intermediate 3 could be manipulated for the preparation of chiral disulphide 7. The amine derivative 5 prepared from (−)-betuligenol showed significant growth inhibition and antifeedant activity.