Influence of [2H]??labelled acetic acid as solvent in the synthesis of [2H]??labelled perhexiline

SC Schou

Index: Schou, Soren Christian Journal of Labelled Compounds and Radiopharmaceuticals, 2010 , vol. 53, # 1 p. 31 - 35

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Abstract

Abstract Preparation of deuterium-labelled perhexiline from an unsaturated analogue was performed via reduction with deuterium gas and PtO 2 in acetic acid. Low incorporation was observed when using acetic acid as solvent (most abundant mass peak was M math image), but when changing the solvent to deuterium-labelled acetic acid, eg acetic acid-OD or acetic acid-d 4, a higher incorporation was observed (most abundant mass peak was M math ...