Stable and selective hybridization of oligonucleotides with unnatural hydrophobic bases
M Berger, AK Ogawa, DL McMinn, Y Wu…
Index: Berger, Markus; Ogawa, Anthony K.; McMinn, Dustin L.; Wu, Yiqin; Schultz, Peter G.; Romesberg, Floyd E. Angewandte Chemie - International Edition, 2000 , vol. 39, # 16 p. 2940 - 2942
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Citation Number: 66
Abstract
Abstract Relying on only interbase hydrophobic packing for bonding, several unnatural nucleobases similar to 1 can form selective and stable self-pairs in duplex DNA. These unnatural nucleobases should make it possible to increase the stringency and information content of hybridization or encoding experiments.
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