Fjord region 3, 4-diol 1, 2-epoxides and other derivatives in the 1, 2, 3, 4-and 5, 6, 7, 8-benzo rings of the carcinogen benzo [g] chrysene

CM Utermoehlen, M Singh, RE Lehr

Index: Utermoehlen, Clifford M.; Singh, Mahatam; Lehr, Roland E. Journal of Organic Chemistry, 1987 , vol. 52, # 25 p. 5574 - 5582

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Citation Number: 39

Abstract

Preparation of 1, 2-dihydrobenzo [g] chryaen-4 (3H)-one (6) and 7, &dihydrobenzo [g] chrysen-5 (6H)-one (1 11, ketones suitable for further elaboration to potential metabolites of benzo [g] chrysene in the 1, 2, 3, 4-and 5, 6, 7, 8-benzo rings, respectively, was achieved through two cyclization steps. Photochemical closure of 241-or 2-naphthy1) styrene derivatives 4 and 9 afforded chrysene and benzo [c] phenanthrene ring systems with a ...