Tetrahedron Letters

An improved large scale procedure for the preparation of N-Cbz amino acids

AD Pehere, AD Abell

Index: Tetrahedron Letters, , vol. 52, # 13 p. 1493 - 1494

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Citation Number: 13

Abstract

... Tetrahedron Letters. ... Tetrahedron, 32 (1997), pp ... Acetone (4.0 vol, with respect to the amino acid) was added and the slightly turbid solution was cooled in an ice water bath to 15–20 °C. Cbz-Cl (1.25 equiv) was added slowly, with stirring, and the reaction mixture allowed to warm ...