Bulletin of the Chemical Society of Japan

Optical Resolution and Stereochemistry of γ-Hydroxyglutamic Acid

YK Lee, T Kaneko

Index: Lee,Y.K.; Kaneko,T. Bulletin of the Chemical Society of Japan, 1973 , vol. 46, p. 3494 - 3498

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Citation Number: 17

Abstract

Four optical isomers of γ-hydroxyglutamic acid were prepared in pure states by optical resolution of two racemic diastereoisomers through brucine salt of N-benzyloxycarbonyl amino acid or strychnine salt of N-benzoyl derivative. Configurations of α-and γ-asymmetric carbon atoms of these isomers were estimated from contribution to molecular rotation and character of taste exhibition. These determinations were confirmed by chemical ...